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KMID : 0624620100430030151
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BMB Reports
2010 Volume.43 No. 3 p.151 ~ p.157
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Membrane associated Ca2+ buffers in the heart
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Lee Duk-Gyu
Michalak Marek
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Abstract
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Ca2+ is a universal signalling molecule that affects a variety of cellular processes including cardiac development. The majority of intracellular Ca2+ is stored in the endoplasmic and sarcoplasmic reticulum of muscle and non-muscle cells. Calreticulin is a well studied Ca2+-buffering protein in the endoplasmic reticulum, and calreticulin deficiency is embryonic lethal due to impaired cardiac development. Despite calsequestrin being the most abundant Ca2+-buffering protein in the sarcoplasmic reticulum, viability is maintained in embryos without calsequestrin and normal Ca2+ release and contractile function is observed. The Ca2+ homeostasis regulated by the endoplasmic and sarcoplasmic reticulum is critical for the development and proper function of the heart.
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KEYWORD
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Ca2+ homeostasis, Calreticulin, Calsequestrin, Endoplasmic reticulum, Heart, Sarcoplasmic reticulum
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